OrbiMed Advisors LLC reported today that on September 6, 2016 entities affiliated with it sold 620,325 common shares of Cynapsus Therapeutics Inc., such that OrbiMed now collectively beneficially owns, controls and directs less than 10% of the outstanding Common Shares of Cynapsus.

The Common Shares were sold by OrbiMed Private Investments V, LP. OrbiMed Capital GP V LLC is the sole general partner of OPI V. OrbiMed Advisors LLC is the Managing Member of GP V. Mr. Samuel D. Isaly is the Managing Member of Advisors. Each of OPI V, GP V and Advisors is organized under the laws of the State of Delaware. OPI V, GP V, Advisors and Isaly are collectively hereinafter referred to as "OrbiMed".

Cynapsus is located at 828 Richmond Street West, Toronto, Ontario M6J 1C9. The address of OrbiMed is 601 Lexington Avenue, 54th Floor, New York, NY 10022.

About OrbiMed

OrbiMed is a leading investment firm dedicated exclusively to the healthcare sector. OrbiMed invests globally across the spectrum of healthcare companies, from venture capital start-ups to large multinational companies utilizing a range of private equity funds, public equity funds, royalty/debt funds, and other investment vehicles. OrbiMed maintains offices in New York City, Herzliya, San Francisco, Shanghai, and Mumbai.